Intermittent Fasting Benefits – Effects of Intermittent Fasting on Health, Aging, Disease – According to Sohal and Weindruch in the year 1997 article in the Journal, reduce in food production over a lifetime (caloric restriction) has incredible effects on aging and the life span in animals. The authors proposed that the health satisfaction of caloric restriction output from the passive reduction in the production of damaging oxygen free radicals.
At the time, it was not generally authorized that because rodents on caloric restriction typically absorb their entire daily food allotment within a few hours after its provision, they have a daily fasting time period of up to twenty (20) hours, during which ketogenesis occurs. Since then, hundreds of studies in animals and scores of clinical studies of controlled intermittent fasting regimens have been conducted in which metabolic switching from liver-derived glucose to adipose cell–derived ketones transpire on daily basis or several days each week.
Even though the magnitude of the effect of intermittent fasting on life-span extension is changeable (influenced by diet, sex, & genetic factors), studies in mice and nonhuman primates show consistent effects of caloric restriction on the health span (see the studies listed in Section S3 in the Supplementary Appendix, available at official site i.e. NEJM.org).
Animals and Humans Studies
Studies in animals and humans have shown that many of the health benefits of intermittent fasting are not simply the result of reduced free-radical production or weight loss.2-5 Instead, intermittent fasting elicits evolutionarily conserved, adaptive cellular reaction that are integrated between and within organs in a manner that improves glucose regulation, increases stress resistance, and suppresses inflammation.
In the course of fasting, cells operate pathways that increase intrinsic defenses against metabolic and oxidative stress and those that remove or repair damaged molecules. At the time of the feeding, cells grab tissue specific processes of plasticity and development. However, most people consume three meal times in a day plus light snacks, so intermittent fasting have not arisen.
Preclinical Studies – Effects of Intermittent Fasting
Preclinical studies consistently show the robust disease-modifying efficacy of intermittent fasting in animal models on a wide range of chronic disorders, including obesity, diabetes, cardiovascular disease, cancers, and neurodegenerative brain diseases.
Periodic flipping of the metabolic switch not only provides the ketones that are necessary to fuel cells during the fasting period but also elicits highly orchestrated systemic and cellular responses that carry over into the fed state to bolster physical and mental output, in addition to disorder resistance.
Here, we review studies in animals and humans that have shown how intermittent fasting influence normal health indicators and reverses or slows aging and disease processes. First, we describe the most commonly studied intermittent-fasting regimens and the metabolic and cellular responses to intermittent fasting.
Article Credit Goes to:-
Rafael de Cabo, Ph.D., and Mark P. Mattson, Ph.D.